Question: Looking Review Paper About P-Value, Adjusted P-Value And Multiple Test In Bioinformatics
gravatar for jack
7.2 years ago by
jack490 wrote:

Hi everyone,

I'm looking for a review paper which gives comprehensive review about P-value, adjusted P-value and common statistical tests in bioinformatics. It would be great if somebody give titles of good ones.

bioinformatics • 3.0k views
ADD COMMENTlink modified 6.9 years ago by Neilfws49k • written 7.2 years ago by jack490
gravatar for brentp
7.2 years ago by
Salt Lake City, UT
brentp23k wrote:

This may be somewhat tangential to your exact question, but you could start by looking at the series "Points of Significance" in Nature Methods (

They have a nice overview of some important ideas. E.g.:

There's not one explicitly about multiple-testing yet, but I suspect it won't be long.

ADD COMMENTlink written 7.2 years ago by brentp23k

Also see for some insights on how to interpret P-values. One of the most striking remarks is the effect of sample size, that is, how you could get significant values with many data points comparing two distributions, although the difference between the means is tiny.

ADD REPLYlink modified 7.1 years ago • written 7.1 years ago by Emre90
gravatar for Dan D
7.2 years ago by
Dan D7.2k
Dan D7.2k wrote:

It's not a journal article per se, but the book Intuitive Biostatistics by Harvey Motulsky provides an excellent overview of the concept of a P value in its first section, and then dedicates a section to the P value wherein he goes into about as much detail as you could possibly want.

ADD COMMENTlink written 7.2 years ago by Dan D7.2k
gravatar for Andreas
7.2 years ago by
Andreas2.5k wrote:

There is also 'How does multiple testing correction work?' (Noble, Nature Biotech, 2009)


ADD COMMENTlink written 7.2 years ago by Andreas2.5k
gravatar for Frédéric Mahé
7.2 years ago by
France, Montpellier, CIRAD
Frédéric Mahé3.1k wrote:

What about p-value misuse? A Dirty Dozen: Twelve P-Value Misconceptions (2008) Steven Goodman, Seminars in Hematology

ADD COMMENTlink written 7.2 years ago by Frédéric Mahé3.1k
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