To my understanding, in the ChiA-PET method we:
- Use formaldehyde to capture the cross-linking of the chromatin
- Digest the chromatin
- In general, ligate the chromatin strands to create pet samples
And in the Hi-C method we perform pretty much the same.
The end result of both should be information on chromatin interactions, so:
- What is the basic difference between the process of ChiA-PET and Hi-C methods?
- What is the difference in the result of the methods?
Yes, my (sort of bad) analogy would be that ChIA-PET is 2-D ChIP-seq and Hi-C is 2-D genome sequencing.