Question: Predict Effects Of Missense Mutations On Structure
gravatar for miquelduranfrigola
6.4 years ago by
miquelduranfrigola760 wrote:

Hi all,

I have a list of ~300 missense mutations. A good proportion of them correspond to aminoacid changes that can be mapped on protein structures. I'd like to assess mutation impact on these structures. Any preferred tool?

Thanks in advance,


structure • 2.8k views
ADD COMMENTlink modified 6.4 years ago by jackuser1979870 • written 6.4 years ago by miquelduranfrigola760

Take a look here: How to study effects of mutations A lot of the good tools listed there are still the same. Also FWIW most of us use the term missense to mean a nucleotide change that results in an amino acid change, so all missense mutations correspond to an amino acid change.

ADD REPLYlink written 6.4 years ago by Alex Paciorkowski3.4k
gravatar for jackuser1979
6.4 years ago by
jackuser1979870 wrote:

You can do with any of kind of molecular visualization tool, for e.g see tutorial of CN3D or you can use STRAP.

If you are working on human, there are per-complied data sets available on MSV3d.

ADD COMMENTlink written 6.4 years ago by jackuser1979870
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