Question: (Closed) Does Transcription Factor Can Also Repress The Expression Of Genes
0
gravatar for jack
6.4 years ago by
jack450
jack450 wrote:

Hi all,

Transcription factors usually increase the transcription of genes. I wonder whether they also can repress the transcription of genes or not ?

ADD COMMENTlink modified 6.4 years ago by Michael Dondrup47k • written 6.4 years ago by jack450
4

jack, I don't see any bioinformatics related problem in you question.
Next time you can ask similar question in http://biology.stackexchange.com/ ("Biology Stack Exchange is a question and answer site for biology researchers") as they should answer in more detail.

ADD REPLYlink modified 6.4 years ago • written 6.4 years ago by PoGibas4.8k
2

Usually they're called "transcriptional repressors" in that case. Look up CTCF for the canonical example. There are likely other examples where whether the factor enhances or represses transcription is context-dependent, but such an example isn't coming immediately to mind.

ADD REPLYlink written 6.4 years ago by Devon Ryan95k

This question does not pertain to bioinformatics and is strictly a biology question -- please refer to the comment from Pgibas above. I am therefore closing the question.

ADD REPLYlink modified 5 months ago by RamRS27k • written 6.4 years ago by Josh Herr5.7k
3
gravatar for bede.portz
6.4 years ago by
bede.portz490
United States
bede.portz490 wrote:

There are certainly examples of transcription factors that regulate genes in response to a stimulus, and the binding of the factor to the genome correlates to both up and down regulated genes.

There is an excellent paper from the Lis and Kraus labs that used a relatively recent technique, GRO-seq to monitor transcription in breast cancer cells genome wide in response to estrogen signalling. The authors employed a novel (in my opinion) hidden Markov model to identify transcripts, including those not yet annotated. This paper is one such example of a factor whose binding correlates to both increased and decreased transcription with similar kinetics, though the mechanism through which a factor may be both negative and positive, seemingly simultaneously, is unclear.

The paper may be of interest from a biological, technical, and analytical perspective

Lis and Kraus paper

ADD COMMENTlink modified 6.4 years ago • written 6.4 years ago by bede.portz490
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