Question: (Closed) Does Transcription Factor Can Also Repress The Expression Of Genes
gravatar for jack
6.4 years ago by
jack450 wrote:

Hi all,

Transcription factors usually increase the transcription of genes. I wonder whether they also can repress the transcription of genes or not ?

ADD COMMENTlink modified 6.4 years ago by Michael Dondrup47k • written 6.4 years ago by jack450

jack, I don't see any bioinformatics related problem in you question.
Next time you can ask similar question in ("Biology Stack Exchange is a question and answer site for biology researchers") as they should answer in more detail.

ADD REPLYlink modified 6.4 years ago • written 6.4 years ago by PoGibas4.8k

Usually they're called "transcriptional repressors" in that case. Look up CTCF for the canonical example. There are likely other examples where whether the factor enhances or represses transcription is context-dependent, but such an example isn't coming immediately to mind.

ADD REPLYlink written 6.4 years ago by Devon Ryan95k

This question does not pertain to bioinformatics and is strictly a biology question -- please refer to the comment from Pgibas above. I am therefore closing the question.

ADD REPLYlink modified 5 months ago by RamRS27k • written 6.4 years ago by Josh Herr5.7k
gravatar for bede.portz
6.4 years ago by
United States
bede.portz490 wrote:

There are certainly examples of transcription factors that regulate genes in response to a stimulus, and the binding of the factor to the genome correlates to both up and down regulated genes.

There is an excellent paper from the Lis and Kraus labs that used a relatively recent technique, GRO-seq to monitor transcription in breast cancer cells genome wide in response to estrogen signalling. The authors employed a novel (in my opinion) hidden Markov model to identify transcripts, including those not yet annotated. This paper is one such example of a factor whose binding correlates to both increased and decreased transcription with similar kinetics, though the mechanism through which a factor may be both negative and positive, seemingly simultaneously, is unclear.

The paper may be of interest from a biological, technical, and analytical perspective

Lis and Kraus paper

ADD COMMENTlink modified 6.4 years ago • written 6.4 years ago by bede.portz490
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