Question: Why Do Bigger Populations (High Ne) Have Lower Ld Values?
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gravatar for GabrielMontenegro
6.2 years ago by
United Kingdom
GabrielMontenegro540 wrote:

Hi everyone:

For example I am talking about LD decay plots that show the level of LD between SNPs at different physical distances.

http://s17.postimg.org/5bsk9j4jz/Screen_Shot_2014_02_02_at_8_47_55_PM.png

Why do Africans for instance have lower levels of LD... if they have always have had a bigger effective population size, isn't there less genetic drift acting on their genomes and therefore haplotypes are NOT being lost? Wouldn't there be more LD?

Thanks in advance.

population ld • 2.0k views
ADD COMMENTlink modified 6.2 years ago by Michael Dondrup47k • written 6.2 years ago by GabrielMontenegro540

Or is it just that because there are more haplotypes, there are more chances of recombination events to occur and therefore less LD???

ADD REPLYlink written 6.2 years ago by GabrielMontenegro540
2

Bigger population = more sex. More sex = more recombination. More recombination is by definition low LD.

ADD REPLYlink written 6.2 years ago by Adrian Pelin2.4k
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gravatar for Michael Dondrup
6.2 years ago by
Bergen, Norway
Michael Dondrup47k wrote:

LD is inverse proportional to genetic variation. The higher the average LD and the larger the LD blocks, the lower the genetic variation or the general number of different haplotypes. African populations where found to have higher genetic variation than eurasians, and mostly eurasian variation is a subset of african variation. This is consistent with the "Out of Africa" theory of the origin of modern humans.

ADD COMMENTlink modified 6.2 years ago • written 6.2 years ago by Michael Dondrup47k
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