Does A Protein Interaction Network Created Directly From Literature Correspond To A Top Down Or A Bottom Up Approach?

Question

[Ashmit]

The protein interaction network created directly from literature (not using any template network or omics data) will be under Top down or Bottom up approach?

[Devon Ryan]

Depends on the data you're mining from the literature

[Ashmit]

I am mining the proteins involve in cell cycling.

[Devon Ryan]

If you're mining information like "A interacts with B" then this would be a bottom-up approach.