Negative values in Cox regression analysis
1
0
Entering edit mode
22 days ago
Mran ▴ 20

Hi there. I am working on gene expression data of a pan-cancer project. I am new in survival analysis and have a question about coxph function in R package "survival". I have z-score of my gene expression levels which contains negative and positive values. the question is ,can I use this data with negative values to perform univariate cox regression analysis? what about multivariate cox regression analysis? Thanks.

survival CoxPH coxregression • 281 views
ADD COMMENT
2
Entering edit mode
22 days ago

Yes, you can use a dataset that comprises both positive and negative Z scores. I am assured that you understand what each value on the Z-scale means? - please see my comment, here: Survival analysis with gene expression

For Cox regression, the fitted residuals for each gene should also follow a normal distribution, which should be virtually guaranteed with a [statistically] powered and balanced [by group] dataset on the Z-scale.

Kevin

ADD COMMENT
1
Entering edit mode

Yes. I have seen your comment very useful. So thanks to you, I am now sure about my path in analysis. Thanks so much

ADD REPLY

Login before adding your answer.

Traffic: 1657 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6