I have a question regarding correct usage of VEP and dbNSFP ... Please help with your valuable insights !!!
I'm using dbNSFP plugin with VEP tool ...
content from dbNSFP read file ...
dbNSFP version 4.2a
Release: April 6, 2021
Major sources: Variant determination:
Gencode release 29/Ensembl 94, released October, 2018 (hg38)
As you can see it says that this version is based on Ensembl 94
VEP tool site for the dbNSFP plugin says ...
"Note that transcript sequences referred to in dbNSFP may be out of sync with those in the latest release of Ensembl; this may lead to discrepancies with scores retrieved from other sources."
Does this mean that when I'm using VEP tool with version as 103, or latest, in offline mode I should get the cache with version as 94 ( that matches the version from which the dbNSFP was derived)?
or can I use the latest version of VEP cache ?
Please help Team !!!