effects of posttranslational protein modifications database?

Question

[Camelia]

Hello! I am searching for a database/tool/anything that is able to tell me if a posttransational modification of a protein (in my case s-glutathionylation) inhibits or not a protein. I have a proteomic analysis from which I see which proteins are s-glutathionylated and which are not. I need to find out which proteins and, even better, pathways end up being altered as a consequence of this s-glutathionylation. For example S-glutathionylation on AMPK-α catalytic subunit activates AMPK whereas glutathionylation of phospho-fructokinase inhibits it. Checking all the proteins one by one is impossible hence my question of a tool that can do it automatically. Can anyone help me with this please? Thanks in advance!

Answer 1

[Elisabeth Gasteiger]

For what it's worth, you may try this query in UniProt and look at the columns "Modified residue" and "PTM":

https://www.uniprot.org/uniprot/?query=annotation%3A(type%3Amod_res%20s-glutathionyl)&columns=id%2Centry%20name%2Creviewed%2Cprotein%20names%2Cgenes%2Corganism%2Cfeature(MODIFIED%20RESIDUE)%2Ccomment(POST-TRANSLATIONAL%20MODIFICATION)&sort=score