I have the following two genes with expression taken from single-cell RNAseq:
As you can see, overall Gene2 has higher expression than Gene1 by order of magnitude. Let say our sample of interest is S3.
The question arise because statistically significant doesn't always mean biologically significant.
How can we confidently say whether Gene2 is more biologically significant than Gene1. And to put it the other way can we safely exclude Gene1 to deem it insignificant?