I'm having some troubles with the indexing of the reference genome (GRCh38) with 'bowtie2-build':
bowtie2-build ReferenceGenome GRCh38_index --large-index
The indexes I've build (by running this cmd) are much more smaller than the genome (GRCh38) indexes that can be downloaded from Bowtie2 website. How is it possible ? What is wrong?
Thanks in advance