Hello, ATAC-seq/DNase-seq are mainly used to identify open chromatin regions/accessible chromatin. H3K27ac is a active enhancer marker. Does anyone know what the relationship of open chromatin regions and H3K27ac? Do all H3K27ac binding sites overlap/intersect with open chromatin regions?
Also, there are reasons for chromatin to be open other than for enhancer activity.
maybe a little intersection of open chromatin regions and H3K27ac peaks