I'm relatively new to analyzing variants data generated by WES in a cohort of cancer patients. I've called variants using Mutect2, annotated them with VEP and now I want to annotate these variants with information such as whether they are known variants in dbSNP and their pathogenicity prediction, whether it's known in ExAC etc.
What tool is the best for doing this type of annotation and also being actively maintained that handles both hg19 and hg38 genome build for cancer genomics? Thanks!!