Hello,

I am developing a model for PRS calculation. For PRS, you need the base data and target data. I have got these datasets however, it is not clear how the model can be used to predict the susceptibility of a trait in a single genome.

Can you please help me understand how PRS calculation is done for an individual genome?

Thanks, Akshay

It is sort of difficult to explain without knowing what the equation is, but essentially you just plug the numbers corresponding to the individuals genetic profile into the general equation ...

Thanks, I am following PRS calculation from this paper: https://www.nature.com/articles/s41596-020-0353-1. From this article, it is clear how to develop a model. The fuzzy thing is regarding its application on an individual genome. That's where I need help.