Determining genes that varying along disease trajectory
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6 weeks ago
sobethon ▴ 10

I have determined a set of differential genes for a set of healthy vs cancerous patient samples. However, for the cancerous samples, there are two groupings, a more mild and a more severe group.

What would be the best way to determine, from our set of differential genes, which generally correlate (positively or negatively) with disease progression, from control -> mild -> severe, or vice versa. Average expression values for single-cells in each group and look for linear relationship?

rna-seq • 74 views
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