assessing relative contribution of samples/ organs towards a diseases in multi-tissue RNAseq
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12 months ago
cwwong13 ▴ 10

I did an RNAseq on multiple tissues (liver, muscle, heart, kidney, etc) on two groups of mice (disease v.s. control). I wonder are there is a type of analysis I can do so that I can conclude the transcriptomic profile is highly shifted in 1 specific organ? I am not sure whether just a comparison of the crude number of DEGs is a valid way to do it.

e.g. I would like to draw a conclusion: Upon the establishment of the disease, the transcriptomic profile in muscle is the most perturbed, thus we are going to focus on understanding the role of muscle on the disease.

RNAseq • 186 views
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