Herald:The Biostar Herald for Friday, August 27, 2021
0
0
Entering edit mode
10 months ago
Biostar 850

The Biostar Herald publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed. You too can submit links here.

This edition of the Herald was brought to you by contribution from Istvan Albert, and was edited by Istvan Albert,


submitted by: Istvan Albert


Introduction - Refgenie (refgenie.databio.org)

An interesting tool to help with downloading references and also pre-built indices.

Refgenie manages storage, access, and transfer of reference genome resources. It provides command-line and Python interfaces to download pre-built reference genome "assets", like indexes used by bioinformatics tools. It can also build assets for custom genome assemblies. Refgenie provides programmatic access to a standard genome folder structure, so software can swap from one genome to another.

submitted by: Istvan Albert


It all started out as a good idea. Have scientists congregate and decide how well software tools work. Alas, it seems it has gone downhill. A 13 tweet thread from Steven Salzberg explains.

submitted by: Istvan Albert


A benchmark of batch-effect correction methods for single-cell RNA sequencing data | Genome Biology | Full Text (genomebiology.biomedcentral.com)

We compare 14 methods in terms of computational runtime, the ability to handle large datasets, and batch-effect correction efficacy while preserving cell type purity. Five scenarios are designed for the study: identical cell types with different technologies, non-identical cell types, multiple batches, big data, and simulated data. Performance is evaluated using four benchmarking metrics including kBET, LISI, ASW, and ARI. We also investigate the use of batch-corrected data to study differential gene expression.

submitted by: Istvan Albert


Autocorrect errors in Excel still creating genomics headache (www.nature.com)

Despite geneticists being warned about spreadsheet problems, 30% of published papers contain mangled gene names in supplementary data.

submitted by: Istvan Albert


Want to get the Biostar Herald in your email? Who wouldn't? Sign up righ'ere: toggle subscription

herald • 312 views
ADD COMMENT

Login before adding your answer.

Traffic: 1734 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6