Job:Flatiron Research Fellow, Biophysical Modeling
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2.2 years ago

Tremendous opportunities for discovery are emerging in the biological and biomedical sciences, as well as in traditional physical and social sciences, but they will require the combined power of theory, data analysis, and simulation. In the biomedical sciences, for example, researchers are being confronted by an explosion of information from genome sequencing, gene expression profiling, proteomics, multi-electrode recording, and multiple high-resolution imaging modalities. The mission of the Center for Computational Biology is to create new computational frameworks that will enable scientists to analyze the large and complex data sets that are being generated by these new experimental technologies. Principle areas of research include biophysical modeling, development dynamics, genomics, and systems biology.

The Center for Computational Biology sits within the Flatiron Institute, an internal research division of the Simons Foundation. The Flatiron Institute is dedicated to advancing scientific research through computational methods, including data analysis, theory, modeling and simulation. It currently It currently houses five science centers, focused on computational astrophysics (CCA), computational biology (CCB), computational mathematics (CCM), computational neuroscience (CCN) and computational quantum physics (CCQ), as well as a scientific computing core.


Applications are invited for a post-doctoral Flatiron Research Fellow (FRF) position with the Biophysical Modeling Group at the Center for Computational Biology (CCB).

In addition to conducting independent research, Flatiron Research Fellows in Biophysical Modeling will develop and apply numerical methods and mathematical models pertaining to phenomena in biophysics, cellular and nuclear biophysics, and collective behavior. In addition, they may work on coarse-graining for many-component systems and inference driven by multimodal experimental data and large-scale simulation. Fellows will also contribute to the efficient and accurate simulation of partial differential equations in complex geometries and on surfaces, especially as applied to fluid-structure interactions, as well as to the group-wide effort to develop code-base for such applications.

More generally, Flatiron Research Fellows will disseminate their results through scientific publication or software release, collaborate with other members of the Center for Computational Biology and/or other Flatiron Institute research centers, and participate in the life of the Center for Computational Biology and the Flatiron Institute by attending seminars, colloquia, group meetings and other opportunities for scientific exchange.

FRF positions are generally two-year appointments and can be renewed for a third year, contingent on performance. FRFs receive a research budget and have access to the Flatiron Institute's powerful scientific computing resources. FRFs may be eligible for subsidized housing within walking distance of the Flatiron Institute.

These positions will be based in our New York City offices.



Applicants are required to have a Ph.D. in applied mathematics, biostatistics, computational biology, computer science, engineering, mathematics physics, or related disciplines or, if selected, will receive their PhD before the start of the FRF appointment.

Related skills and other requirements

  • Exceptional abilities in mathematical modeling, analysis and/or scientific computation, scientific software and algorithm development, and data analysis
  • Ability to do original and outstanding research in computational biology
  • Ability to work well in an interdisciplinary environment, and to collaborate with experimentalists
  • Experience with Bayesian inference, network inference, and image analysis preferred
  • Strong oral and written communication, data documentation, and presentation skills
  • Excellent collaborative and interpersonal skills required.


  • Cover letter (optional)
  • Curriculum vitae with bibliography
  • Research statement of no more than three (3) pages describing the applicant's past work, proposed research program, and potential synergies with activities at CCB
  • Two (2) letters of recommendation submitted confidentially by the recommenders directly to


Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds and experiences, and we are committed to cultivating an inclusive work environment. The Simons Foundation actively seeks a diverse applicant pool and encourages candidates of all backgrounds to apply. We provide equal opportunities to all employees and applicants for employment without regard to race, religion, color, age, sex, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status, or any other protected category under federal, state and local law.

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