The Dorrity group at EMBL Heidelberg is seeking a highly motivated computational biologist to act as a Laboratory Officer, helping to set up a new lab that promotes a welcoming and positive atmosphere. Our group uses single-cell genomics as a whole-organism phenotyping tool in zebrafish to (1) understand how different cell types respond to environmental stress and (2) to build statistical models of developmental robustness. Ultimately, we aim to predict how a changing climate will influence animal development. If this goal aligns with your own, and you are eager to improve your skillset in a leading research environment, then we want to hear from you.
Your role The position will entail analysis of single cell genomic data (scRNA-seq or scATAC-seq) in collaboration with experimental and computational biologists in the lab. The successful candidate will lead analyses of the molecular and cellular determinates of stress sensitivity, acceleration of developmental rate, and variable cell type compositions of individuals in populations of developing embryos. This will require interfacing with multi-modal single-cell genomics data that contain information on both gene expression and whole-animal cell type abundances. Deploying methods to integrate these data types with others will be necessary to successfully address the primary goals of the lab. You will also work closely with the lab head to build computational pipelines for analysis of new datasets that can be used by other lab members. As a lab officer, you will help onboard new lab members, coordinate lab jobs, and manage reagent and equipment orders.
You have You should have a Ph.D. in computer science, bioinformatics or biostatistics, or at least five years of working experience in the capacity of a computational biologist. Prior experience with analysis of genomics data (RNA-seq, ATAC-seq, DNA-seq, or single-cell adaptations thereof), R, scripting languages (e.g. python) and strong familiarity with the unix shell is a must. Significant experience in statistical analysis and modeling is required. The candidate will have an independent work plan and a willingness to interact with other team members in a hybrid wet/dry lab environment.
The successful applicant will be organized, open-minded, and an avid communicator. Being able to manage multiple projects and effectively interact with different groups of people will be necessary. A working knowledge of English is essential.
You might also have Experience in multi-omics data integration Experience with generalized linear model implementations in R (VGAM, glmnet) Familiarity with machine learning methods and approaches Experience with climate or ecological modeling using existing databases Background or previous experience working with aquatic organisms / fish Understanding of molecular and sequencing techniques for single-cell genomics
Why join us EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus.
What else you need to know We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with approximately 2000 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.
Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.
Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.
Please follow the link below to apply, https://www.embl.org/jobs/position/HD02022