Correcting for leukocyt count in QuantSeq analysis

Question

[Barista]

I am conducting a human whole blood QuantSeq analysis. Is it true that WBC count can influence the results of the analysis and should I correct for it (in the design matrix)?

[Barista]

Anyone has any ideas?

[ATpoint]

What is the aim of the analysis?

[Barista]

Exporering which genes are differentially expressed between two conditions (in humans). The condition lead to the same clinical syndrome, but also have some differences. To be more specific, the suggestion was to correct for specific WBC cell counts (so basophils, neutrophils, lymfocytes, monocytes and eosinophils).