Copy Number Variant detection without control

Question

[GenoTechUser]

I'm trying to detect for the Copy number variants (CNVs) from Whole Exome Sequencing (WES) data.

However, the catch is I do not have a control data.

Can you please suggest a tool for the detection of CNVs from WES data?

Thank You

Answer 1

[shiyang_bio]

CNVkit can do this by setting a "flat" control

[GenoTechUser]

Thank You. We will explore this option in 'CNVkit'