genomic coverage
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4 months ago
Rob ▴ 120

Does anyone know the answer for this: why you expect the genomic variation coverage?

RNA-Seq • 370 views
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the way that this question is posed sounds very much like homework. it is not looked upon kindly to ask a homework problem without showing any attempt of solving it yourself

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Thanks I did attempt and was not sure about the accuracy of my answer. that is why I asked here. this is my answer: there naturally is variation in sequencing coverage due to many factors, like repeatetive elements, GC percentage, and just by chance. so the coverage will vary.

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that's quite correct, thus I feel fine answering a homework question: add mappability problems (related to repetitive elements but not limited) and imperfect human genome reference and common copy-number polymorphisms

However I may also be wrong - it all depends on what the person who made this question assumed within which course

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