Does anyone know the answer for this:
why you expect the genomic variation coverage?
the way that this question is posed sounds very much like homework. it is not looked upon kindly to ask a homework problem without showing any attempt of solving it yourself
Thanks I did attempt and was not sure about the accuracy of my answer. that is why I asked here. this is my answer: there naturally is variation in sequencing coverage due to many factors, like repeatetive elements, GC percentage, and just by chance. so the coverage will vary.
that's quite correct, thus I feel fine answering a homework question: add mappability problems (related to repetitive elements but not limited) and imperfect human genome reference and common copy-number polymorphisms
However I may also be wrong - it all depends on what the person who made this question assumed within which course
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