Log-Transformed Upper-Quantile Normalization for RNA-seq Counts

Question

[Neda]

Dear all, My goal is to perform Log-Transformed Upper-Quantile Normalization on RNA-seq data. And then do Linear Regression (LASSO). I would appreciate it if anyone could tell me what tool or server I should use for each part?

[ATpoint]

Do you have knowledge of R or any other language or does it need to be click&do / GUI solution?

[Neda]

I'm familiar with R and Python, but I'd rather use a simpler solution. I'd appreciate any suggestions you may have.