Hello all, I am new to R programming and I would like your help in suggesting a strategy to solve the following question. I have gene expression data and protein expression data which has the same samples. I want to identify differentially expressed genes by comparing both datasets. So for this I have tried first merging both the datasets and performing differential expression using limma, then I have also tried taking ratio or gene: protein and performing a differential expression using limma. All these strategies were not successful as I got a weird volcano plot as I have attached below. I would be very grateful if someone suggest me a strategy or a method by which I can perform this analysis.