I'm trying to understand how to work with microrna data and I am having some struggles with the nomenclature.
If I understood correctly from this Biostars post:
hsa-miR-373-3p and hsa-miR-373-5p have to be considered like different miRNAs because they have different sequences and consequently different targets.
Instead, hsa-miR-101-1 and hsa-miR-101-2 have the same target; but come from different loci.
If I have an expression value for hsa-miR-101-1 and one for hsa-miR-101-2, and I want to see how much their target gene is regulated, can I sum the two expression values and consider them only once?
What if I have two miRNAs like hsa-miR-190a and hsa-miR-190b? From this article (NewsMedicalLifeSciences), it seems like they are different miRNAs but of the same family. What does that mean? Do they target the same genes?
If I have data from different sources how can I handle merging them?
If one source only has hsa-miR-101 and the other hsa-miR-101-1 and -2? Is it referring to both?
What if one source only has hsa-miR-373 and the other hsa-miR-373-3p and -5p?
It cannot be referring to both, but, from what I understood, one is usually more stable than the other. I guess it could be referring to that one. Where would I find the information about which arm to consider?