RNA-Seq, ciBioportal, mutation, copy number
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2.2 years ago
Rob ▴ 170

when looking at the genes that are enriched in the altered group and also they all have same Cytoband. why these genes are highly significant in this analysis? https://ibb.co/S0gc7Hp image from cbioportal

is it a correct explanation: EGFR-AS1 or EGFR antisense RNA 1 is an antisense RNAs (asRNAs). So, it is a small molecule that perform their regulatory function by recognizing sequence and structural elements that are present in itself and their target mRNAs. So, it regulates and alters the expression of the sequence close to itself. As these gene have the same cytoband, they are close to EGFR-AS1. So, EGFR-AS1 can regulated all of these genes and they all are enriched.

RNA-Seq • 449 views
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