Ancient DNA Analysis Fastq to vcf
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3 months ago
Aruna ▴ 20

When combining multiple sample into vcf file, is it necessary that all samples must be aligned to the same reference build version ? such as Grch38, 37 etc.,

vcf genome genotyping dna file ancient 38 19 buils • 169 views
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3 months ago
tacrolimus ▴ 100

Dear Aruna,

Yes! You will have to do a liftover from one build to another before merging into a single VCF

All the best

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