Dear community members,
I feel quite comfortable with structural variants calling in WGS (human rare disease) except between-chromosome translocations. I use Manta for calling and I normally have tens to hundreds of "translocations" per sample.
How can I understand if a translocation is real?
I know that some of them are recurrent and thus anything that occur in a known region deserves a second look, but what about non-recurrent ones?