New Human genome FASTA
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2.2 years ago
Raman2 ▴ 30

Hi!

How do we access the newly published complete human sequence. (https://www.science.org/doi/10.1126/science.abj6987)

Is GRCh38.p14 the new complete version of genome?

Thanks!!

ReferenceGenome • 1.2k views
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2.2 years ago
GenoMax 143k

You can find CHM13 T2T assembly here (LINK for NCBI page) and direct LINK for sequence. I don't think it is appropriate to call it GRCh38.p14. Since this sequence is from a specific cell line I doubt it will get that patch name. In any case GENCODE is the official organization that releases site is where you will find authoritative human genome builds.

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Thank you GenoMax! Can we use this as the new reference genome or should we still be using the existing gencode genome (GRCh38.p14)

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For continuity and compatibility with existing annotation current GENCODE genome would still be the safe bet.

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In any case GENCODE is the official organization that releases authoritative human genome builds.

Genome Reference Consortium is the one that releases GRC genome assemblies such as GRCh38.p14.

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