New Human genome FASTA

Question

[Raman2]

Hi!

How do we access the newly published complete human sequence. (https://www.science.org/doi/10.1126/science.abj6987)

Is GRCh38.p14 the new complete version of genome?

Thanks!!

Answer 1

[GenoMax]

You can find CHM13 T2T assembly here (LINK for NCBI page) and direct LINK for sequence. I don't think it is appropriate to call it GRCh38.p14. Since this sequence is from a specific cell line I doubt it will get that patch name. In any case GENCODE is the official organization that releases site is where you will find authoritative human genome builds.

[Raman2]

Thank you GenoMax! Can we use this as the new reference genome or should we still be using the existing gencode genome (GRCh38.p14)

[GenoMax]

For continuity and compatibility with existing annotation current GENCODE genome would still be the safe bet.

[vkkodali_ncbi]

In any case GENCODE is the official organization that releases authoritative human genome builds.

Genome Reference Consortium is the one that releases GRC genome assemblies such as GRCh38.p14.