addModuleScore and enrichment score methods

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2.1 years ago

lsudupe ▴ 20

I am working with different enrichment score methods like AUCell and ssGSEA. Now I am trying the seurat function addModuleScore but I am not understanding the method.

For the addModuleScore I couldn't find a good explanation of the method. In the source code they reference "Tirosh 2016, "Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq", I went through it but I do not understand it well.

Are the enrichment score I get in AUCell and ssGSEA or the moduleScore I get with the seurat function the same?

Do the average expression levels and the enrichment score means the same?

Thanks in advance

expression enrichment gene score addModuleScore • 3.1k views

ADD COMMENT • link 2.1 years ago by lsudupe ▴ 20

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Detailed read on the matter

ADD REPLY • link 2.1 years ago by fracarb8 ★ 1.6k

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Thank you for the link

ADD REPLY • link 2.1 years ago by lsudupe ▴ 20

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