Is ATAC-seq libraries consider as reduced representation libraries ?

Question

[adR]

Hi everyone,

From the ATAC-Seq protocol, I intend to conduct methylation analysis. Just wondering if ATAC-seq sequences are reduced representation libraries or not? The reason I ask is that ATAC-seq does not sequence the whole genome, but only open chromatin regions, as I understand it.

Best, Amare

[ATpoint]

What does ATAC-seq has to do with methylation? Yes, it is a reduced representation library in terms of that you highly enrich for certain genomic regions.

[adR]

ATpoint, not sure 100% but methyl-ATAC-seq can measure DNA methylation at accessible chromatin. find the link below.

https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6581052&blobtype=pdf