Need help in explanation about article's binary hypothesis
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11 days ago
khanhlpbao • 0

Hi everyone Before we get into my problem, I'm sorry if this post make you feel uncomfortable for asking a similar question but I have tried for multiple months, ask multiple people but no one has enough biostartistics knowledge to explain me about this. I'm working with NIPT data and I found this article about NIFTY algorithm (Jiang, F., Ren, J., Chen, F., Zhou, Y., Xie, J., Dan, S., Su, Y., Xie, J., Yin, B., Su, W., Zhang, H., Wang, W., Chai, X., Lin, L., Guo, H., Li, Q., Li, P., Yuan, Y., Pan, X., Li, Y., … Zhang, X. (2012). Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies. BMC medical genomics, 5, 57. https://doi.org/10.1186/1755-8794-5-57). In the section "Autosomal aneuploidy detection with binary hypothesis" on Methods part (page 9), the second t-value is calculated by cri,j - cr'i,j(1+epsilon_i/2). I don't know what is epsilon i means, there is no explanation on the article. In the same page and section, the logarithmic likelihood odds ratio formula contain the log of two p, I don't know what is those p means. Thank you very much for helping me.

nipt t-test • 97 views