Herald:The Biostar Herald for Monday, August 29, 2022
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The Biostar Herald publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed. You too can submit links here.

This edition of the Herald was brought to you by contribution from GenoMax, Istvan Albert, and was edited by Ram, Istvan Albert,

The Toxic Culture of Rejection in Computer Science – ACM SIGBED (sigbed.org)

We have come to value as a quality metric for conferences a low acceptance rate. This feeds a culture of shooting each other down rather than growing and nurturing a community. The goal of a PC has become to destroy rather than to develop. Many of our venues are proud of their 10% acceptance rates. Are such low acceptance rates justified?

submitted by: Istvan Albert

Fast and Accurate Kinship Estimation Using Sparse SNPs in Relatively Large Database Searches | bioRxiv (www.biorxiv.org)

Forensic genetic genealogy (FGG) has primarily relied upon dense single nucleotide polymorphism (SNP) profiles from forensic samples or unidentified human remains queried against online genealogy database(s) of known profiles generated with SNP microarrays or from whole genome sequencing (WGS).

By focusing on SNPs with maximal discriminatory power and using an algorithm designed for a sparser SNP set than those from microarray typing, performance similar to segment matching was reached even in difficult casework samples.

submitted by: Istvan Albert

Ultima Unveiling: Big Black Box Sparks Preprint Debate | GEN Biotechnology (www.liebertpub.com)

Ultima Genomics emerged from stealth in June with a well-orchestrated campaign for its novel DNA sequencer and lofty claims of delivering a $100 genome, garnering both attention and skepticism.

submitted by: Istvan Albert

Omics! Omics!: SRA Entries Should Not Ever Disappear Into Thin Air (omicsomics.blogspot.com)

submitted by: Istvan Albert

submitted by: Istvan Albert

https://www.youtube.com/watch?v=GNyQxXw_oMQ&feature=youtu.be (youtu.be)

Kernighan the "K" in AWK

submitted by: GenoMax

Synonymous mutations in representative yeast genes are mostly strongly non-neutral | Nature (www.nature.com)

Three-quarters of synonymous mutations resulted in a significant reduction in fitness, and the distribution of fitness effects was overall similar—albeit nonidentical—between synonymous and nonsynonymous mutations.

submitted by: Istvan Albert

The revolutionary Nature paper that wasn't (stuartritchie.substack.com)

A CRISPR study claimed to upend the established science on genetic mutations. Did it?

submitted by: Istvan Albert

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