node rewiring analysis using DyNet app in the Cytoscape

Question

[adR]

Hi everyone, 1st of all, thanks for answering my question. I have three different network data such as network1, netnetwork2, and network3, for A, B, and C conditions. I would like to find the most changing nodes across these networks. Thus, I used the DyNet app in Cytoscape. However, the most rewired node belongs only to the network1, which is condition A specific.

My question is:

1. how a rewiring node could be condition specific?

below is the link for the software. https://apps.cytoscape.org/apps/dynet

Best, adr

Answer 1

[Scooter]

Greetings,

I'm not that familiar with DyNet, but I can certainly take a shot at answering your question. Basically, assume you have 3 networks: A, B, and C that represent 3 different conditions. Networks B and C are very similar, but a node in network A shows significantly different edges than either network B or C. Therefore, that node will be the most significantly rewired node, but only in network A.

-- scooter

[adR]

@Scooter, thanks for taking the time to answer my question. If I understand your answer, a node with unique edges in one condition compared to two or more networks is regarded as the most rewired node for the specific network. Is this because the rewired node which is group-specific has no edges in B and C networks?