Bioinformatics analysis from raw data to disease driver variants

Question

[mathewarkit]

Hi!

I have a doubt! Which bioinformatics analysis would you perform to prioritise disease driver variants from raw sequencing data? Along with computational methods, file formats, quality measures, controls, annotation and statistics to assign genomic disease?

I have been asked for it and I can't find any proper literature to answer it

Thanks!

[Pierre Lindenbaum]

map those raw sequencing data to a reference genome, extract the variants, filter the variants according to the studied disease.

[Jeremy Leipzig]

I have no doubt. Just google "variant prioritization".

[mathewarkit]

Thank you! I will google it right now!

[brunobsouzaa]

Search for GATK Best Practices