mitch analysis report priority by standard deviation
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16 months ago
Amr ▴ 160

When I prioritize mitch analysis report by standard deviation (SD), what does it mean? depending on what the ordering of the gene sets in the results table was performed?

mitch standard_deviation • 423 views
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12 weeks ago
mark.ziemann ★ 1.9k

Let's say you are analysing 3 contrasts together with mitch, each gene set will have enrichment scores for each of the 3 contrasts. When you prioritise by SD, you are looking for gene sets that have highly discordant regulation in the 3 contrasts. This can be interesting if you are doing single cell RNA-seq analysis and interested in how the different cell types are behaving in disease. https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-020-06856-9

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