Example of Phylogenetic Tree Construction by MLE?
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Entering edit mode
16 months ago
nickarsimet ▴ 30

Could someone direct me to a resource (textbook chapter, lecture notes, online video, etc.) that demonstrates, in a mathematically or computationally rigorous way, how to use maximum likelihood estimation to generate a phylogenetic tree, given a set of aligned sequences?

I've found several resources which describe the procedure for maximum likelihood estimation, such as giving the formula and the parameters that need to be determined (which I already know) and how to use it for aligned sequences (I already know this), but I really would like a worked-out example so that I can confirm my own mathematical thought process and make sure I am doing it right. I can't find anywhere that shows me how to do it from beginning (start with nothing but sequence alignments) to end (arrive at a tree).

Alternatively, if someone is willing to work out a small example, how would you use maximum likelihood estimation to generate a tree for the following three sequences?

organism_1 ATCG
organism_2 ATCC
organism_3 ATTT
mle phylogeny genomics sequencing phylogenetics • 485 views
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Entering edit mode
16 months ago

I believe, Felsenstein 1981 originally postulated using MLE for the construction of phylogenetic trees. Cho 2012 nicely elaborates on the original publication and might be the missing link you are looking for?

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