The Laboratory of Experimental Gastroenterology at the Université Libre de Bruxelles (ULB), Brussels, Belgium, is recruiting a Postdoc in Bioinformatics.
Our research focuses on discovering chronic liver disease's environmental and genetic determinants, particularly on the development of liver cancer and cirrhosis-related complications. We mainly utilize genomics and single-cell transcriptomics data. The successful applicant will take a lead role in this setting and work on a large-scale EU-funded project. More specifically, the aim will be to identify novel human genetic variations and other environmental risk factors predisposing to hepatocellular carcinoma development.
Duration: 1 year full-time with a possibility for prolongation of up to 5 years.
Starting date: As soon as possible till a suitable candidate is found.
The ULB has a reputation for excellence in basic and applied biomedical research and is an active member of the European Research Area https://www.ulb.be/en/ulb-homepage. The ULB is involved in almost 80 EU-funded projects. The Laboratory of Experimental Gastroenterology is a translational research team within the Gastroenterology, Hepatopancreatology, and Digestive Oncology Department of the Hôpital Universitaire de Bruxelles, Brussels, Belgium https://www.hubruxelles.be/en. The group, led by Prof. Eric Trépo, uses genome-wide association studies (GWAS) and single-cell genomics to identify risk factors, better understand the pathophysiology of chronic liver diseases and pinpoint potential therapeutic targets [1-3].
 Trépo E, et al. Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study. Lancet Oncol. 2022;23:161-171
 Trépo E, et al. Combination of gene expression signature and model for end-stage liver disease score predicts survival of patients with severe alcoholic hepatitis. Gastroenterology 2018;154:965-975
 Buch S, et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet. 2015;47:1443-1448
- Use state-of-the-art and novel computational strategies to identify environmental risk factors and genetic variants linked to liver cancer/cirrhosis complications.
- Analyze GWAS and single-cell datasets.
- Support research and development activities within the group.
- Maintain accurate and detailed records of research activities.
- Support the group leader in the management of a large-scale EU-funded project.
- Support the group leader in training new group members.
- Ph.D. in Bioinformatics, Computational Biology, Physics, Engineering or equivalent.
- Programming experience with R and Python.
- Expertise in analyzing GWAS and associated tools (e.g., PLINK, METAL).
- Expertise in analyzing single-cell datasets (transcriptomics, metabolomics, …).
- Training and/or expertise with whole exome/genome sequencing is a plus.
- Strong organizational and record-keeping skills.
- Enthusiasm to work in a multi-disciplinary, collaborative environment.
- Proficient written and spoken English language skills.
- A highly motivated multidisciplinary research team including biologists, bioinformaticians, and clinicians and the possibility to participate in international collaborations.
- A salary of approximately 2500€ after-tax - commensurate with experience - and social benefits (e.g., health coverage, social security, etc.).
- Mentoring and career development opportunities.
Applications should be sent with a cover letter, Resume/CV, and at least two references directly to Mr. Eric Quertinmont at firstname.lastname@example.org and Prof. Eric Trépo at email@example.com.
Read more about the post and apply online:
Application deadline: Until the position is filled.