I have a VCF file of only SNPs. what I wish to do is for every SNP to download the CADD score
from here: https://cadd.gs.washington.edu/download
. I'm new to genetics and I'm not sure which file should i download for this :
is it the Genome build GRCh37 / hg19-All possible SNVs of GRCh37/hg19 or All possible SNVs of GRCh38/hg38 or the All gnomAD SNVs (release 2.1.1)? I'm suspecting that I should download All possible SNVs of GRCh38/hg38 (but it is a very big-81G, if this is the file would appreciate to know what is the code to download it in UBUNTU is this the same as downloading gnomad data?)
This is what my VCF file to which I would like to add the CAAD scores looks like :
Thank you . Just to make sure if I'm working with SNPS is this file the correct one All possible SNVs or should I use the gnomad option there ?
gnomAD and CADD are different resources.
from CADD website
from gnomAD website
I suggest you go to their sites and click around a bit to see what they are about.