What are some recommended tools either in linux command line or R that people use to meta-analyse rare-variant gene burden analysis generated from whole genome sequencing data?
I have summary stats from two separate case-control cohorts with gene-level P-values and betas but not the individual variants that make up each gene. These were generated using SAIGE-GENE.
RARE-METAL seems to require variant level info so I am not sure it is the right one to use...
All the best