We are currently seeking a highly motivated Senior Bioinformatician in human genome sequencing for the Oxford Biomedical Research Centre (BRC) Genomic Medicine Theme, based at the University of Oxford’s Wellcome Centre for Human Genetics (WHG), within the group of Associate Professor Jenny Taylor. This is an exciting opportunity for a committed and ambitious individual to apply and develop their bioinformatics expertise in a cutting-edge field of genomics.
You will develop and apply bioinformatics pipelines for analysis of human genome sequencing data (including short and long read sequencing) including alignment, calling, annotation and interpretation of single nucleotide, copy number, non-coding and structural variants. You will develop novel algorithms to improve the performance of the pipeline and address annotation of variants in regulatory and non-coding regions, and undertake analysis and interpretation of data in the Genomics England (GEL) national 100,000 Genomes Project, particularly including the musculoskeletal domain. The role will also involve integration of multi-omics datasets including transcriptomics and proteomics.
It is essential that you hold a PhD in Bioinformatics or Statistical Genetics, and have strong postdoctoral experience in analysis and interpretation of human whole genome sequencing data. You will have previous experience with relational databases and SQL language. Prior responsibility for developing, improving and maintaining bioinformatics pipelines using a workflow management system like Nextflow, Snakemake or WDL, and demonstrating commitment to quality and version control and secure data management, is required.
Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.
This post is offered full-time on a fixed term until 28 February 2025, and is funded by the Medical Research Council.
Only applications received before 12 midday on Thursday 2 February 2023 will be considered. Interviews for this position will be held on Wednesday 8 February 2023.
Please quote 162403 on all correspondence.
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