MetaboAnalyst: Interpreting Enrichment Analysis Results
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16 months ago
eva_u ▴ 10

Hello,

In the Quantitative Enrichment Analysis result table (img1 below): each time I ran the analysis the raw p-values seem to be inversely related to the q-values. How should I interpret this? And which results should I consider significant? E.g. if I go with the standard for raw p-value (<0.05), I'm getting very high (significantly above expected) q-value; if I go with a low q-value, p-value is beyond anything considered to be significant? Could this indicate problem with the data?

Also, for the box plots showing relative abundance of the hit metabolites: all of mine have values above and 0 zero. Should I interpret that as above normal (i.e. reference) abundance and below normal abundance (img2 below)?

Thank you!

Here's an example: QEA results table

enter image description here

enrichment metabolomics • 546 views
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Note: it seems I have confused Q statistic with the Q- value; please disregard the 1st part of the question

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