Herald:The Biostar Herald for Monday, February 20, 2023
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This edition of the Herald was brought to you by contribution from Istvan Albert, and was edited by Istvan Albert,

submitted by: Istvan Albert

submitted by: Istvan Albert

Urgent need for consistent standards in functional enrichment analysis | PLOS Computational Biology (journals.plos.org)

We find that 95% of analyses using over-representation tests did not implement an appropriate background gene list or did not describe this in the methods. Failure to perform p-value correction for multiple tests was identified in 43% of analyses.

submitted by: Istvan Albert

Multiple sources of bias confound functional enrichment analysis of global -omics data | Genome Biology | Full Text (genomebiology.biomedcentral.com)

Serious and underappreciated sources of bias mean that extreme caution should be applied when using or interpreting functional enrichment analysis to validate findings from global RNA- or protein-expression analyses.

submitted by: Istvan Albert

submitted by: Istvan Albert

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