Meaning of stat values in DESeq2 result

Question

[woongjaej]

Hello, experts.

I'm curious what will be the meaning of stat values in the DESeq2 result.

For example, if geneA has a stat value for 50, and geneB has a stat value for 20, what is the overall comparison meaning of these two genes?

Any comments are appreciated!

Thanks

Answer 1

[ATpoint]

Please read the documentation and functions help.

?results

(...) For the Wald test, stat is the Wald statistic: the log2FoldChange divided by lfcSE, which is compared to a standard Normal distribution to generate a two-tailed pvalue. For the likelihood ratio test (LRT), stat is the difference in deviance between the reduced model and the full model, which is compared to a chi-squared distribution to generate a pvalue.