I would like to ask for a suggestion on whether I could fit a CNA profile of a sample that I do have to known CNV signatures.
I have used the package sigminer, that seems to focus entirely on CNV signature discovery nowadays, and not on fitting of a sample CNV to known CNV profiles (that are listed on https://cancer.sanger.ac.uk/signatures/cn/)
Given the data in the format :
*Chromosome Start.bp End.bp modal_cn minor_cn sample 1 chr1 1439593 2042815 3 1 EA5040545.EA5040598 2 chr1 2425333 5924715 1 0 EA5040545.EA5040598*
which package shall I use in the order to find the proxy of my sample to known CNA signatures ?
Thanks a lot,