Hello, I have performed Whole-Genome sequencing experiments on two patients blood (human) and one mouse (tail DNA).
Using this data I want to calculate the CNV.
Due to the fact that I do not have any kind of control, I read about several methods related to the general deep coverage of the experiment leading to identifying segments, and so possibly a CNV, without using controls.
I have right now the BAM files obtained using BWA-mem. Can you suggest to me some tools or a general pipeline that will work to identify CNV without controls?
Thank you! Francesco