I made a video on making heatmap with R and how to understand it deeply https://www.youtube.com/watch?v=7fQkPUqusTg
The Rmarkdown file https://github.com/crazyhottommy/compbio_tutorials/blob/main/scripts/01_how_to_make_a_heatmap.Rmd
If you use python, do not worry; take a look at https://github.com/DingWB/PyComplexHeatmap
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