how to look for interactions between different chromosomes

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10 months ago

rheab1230 ▴ 140

Hello everyone, I have a HiC data which has chromosomal interaction. But this dataset has chr20 region interacting with chr20 region. I want to look for datasets that have inter chromosomal interactions. like chr20 region interactin with chr2 region. Is there any mechanism to explain these interactions between different chromosomes? Mainly enhancer regulator interactions is only chromosome wise. Or transcription factor also regulates same chromosomes genes Thank you.

SNP interactions Gene HiC • 527 views

ADD COMMENT • link 10 months ago by rheab1230 ▴ 140

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I don't think it is possible. HiC resolution is limited even for intra-chromosome interactions, and most bioinformatic tools discard reads mapping discordantly to more than one chromosome.

ADD REPLY • link 10 months ago by Buffo ★ 2.4k

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apart from tool, is there any biological mechanism for explanation of interactions between different chromosomes?

ADD REPLY • link 10 months ago by rheab1230 ▴ 140

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